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[Safety Assessment, Discovery and Translational Sciences]

Beyond Fragmentation: Inotiv’s Unified Tox Network Accelerates Discovery

Beyond Fragmentation: How Inotiv’s Unified Toxicology Network Accelerates Drug Development

[Animal Research, Research services, Research models, DIO]

Enhancing Health Monitoring with Sentinel Free Filter Testing (SiFT)

A healthy rodent colony is vital to the scientific integrity of research results, emphasizing the importance of monitoring colonies for pathogens. However, reliably detecting pathogens can be...

[Animal Research, Research services, Research models, DIO]

The expanding reach of GLP-1 research and the role of the diet-induced obesity (DIO) model

Glucagon-like peptide-1 (GLP-1) agonists, such as semaglutide and liraglutide, are major anti-obesity and anti-diabetes therapeutics that have produced clinically meaningful metabolic benefits. While...

[Discovery, psoriasis, disease models, inflammation, dermatology]

Strain Selection for IMQ-Induced Psoriasis Studies

The imiquimod (IMQ)-induced psoriasis model is widely used in preclinical dermatology research due to its ability to rapidly generate localized skin inflammation that resembles key features of human...

[Safety Assessment, medical device testing, orthopedics, histopathology, medical device pathology, histology, pathology]

The Role of Histopathology in Orthopedic Medical Device Assessment

The evolution and diversity of orthopedic medical devices has progressed significantly over recent years, thanks to advancements in both material innovation and technological capabilities. The...

[Safety Assessment, pathology, artificial intelligence, Discovery and Translational Sciences, cardiomyopathy, toxicologic pathology, intra-rater agreement, inter-rater agreement, PCM]

Improving Accuracy: AI-Based Scoring and Its Impact on Cardiomyopathy Assessment

Artificial intelligence is increasingly gaining traction in pathology, offering tools for tumor detection, object identification, and tissue quantification. A recent study co-authored by Inotiv’s Dr....

[safety pharmacology, toxicology, Telemetry, Safety Assessment, cardiovascular]

Understanding ICH E14/S7B Best Practices for Nonclinical Studies

The landscape of drug development requires a comprehensive approach to ensure safety, particularly concerning cardiac function. The ICH E14/S7B guidelines represent a significant step forward in...

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