Inotiv Blog

[Discovery, psoriasis, disease models, inflammation, dermatology]

Strain Selection for IMQ-Induced Psoriasis Studies

The imiquimod (IMQ)-induced psoriasis model is widely used in preclinical dermatology research due to its ability to rapidly generate localized skin inflammation that resembles key features of human...

[Safety Assessment, medical device testing, orthopedics, histopathology, medical device pathology, histology, pathology]

The Role of Histopathology in Orthopedic Medical Device Assessment

The evolution and diversity of orthopedic medical devices has progressed significantly over recent years, thanks to advancements in both material innovation and technological capabilities. The...

[Safety Assessment, pathology, artificial intelligence, Discovery and Translational Sciences, cardiomyopathy, toxicologic pathology, intra-rater agreement, inter-rater agreement, PCM]

Improving Accuracy: AI-Based Scoring and Its Impact on Cardiomyopathy Assessment

Artificial intelligence is increasingly gaining traction in pathology, offering tools for tumor detection, object identification, and tissue quantification. A recent study co-authored by Inotiv’s Dr....

[safety pharmacology, toxicology, Telemetry, Safety Assessment, cardiovascular]

Understanding ICH E14/S7B Best Practices for Nonclinical Studies

The landscape of drug development requires a comprehensive approach to ensure safety, particularly concerning cardiac function. The ICH E14/S7B guidelines represent a significant step forward in...

[Safety Assessment, medical device testing, orthopedics, histopathology, medical device pathology, histology, pathology]

Healing Redefined: The Role of Bioabsorbable Implants in Modern Medicine

The growing field of biodegradable medical implants offers significant advantages, particularly in reducing the need for secondary surgeries and minimizing long-term complications that can arise from...

[Safety Assessment, mechanical testing, medical device testing, medtech, surgical support for medical device, orthopedics, device evaluation, histopathology, plastic pathology, preclinical research]

From Promise to Practice: Evaluating Magnesium-Based Medical Devices in Preclinical Studies

The growing field of biodegradable medical implants offers significant advantages, particularly in reducing the need for secondary surgeries and minimizing long-term complications that can arise from...

[Discovery, Safety Assessment]

Novel Polymer-Based Orthopedic Implant Shows Complete Integration, Healing, And Safety In A Multi-Year Sheep Study

Key Takeaways: Traditional inert and bioabsorbable orthopedic implants demonstrate several drawbacks, including inflammation or infection, often requiring follow-up surgeries. A biointegrative,...